Systemic Lupus Erythematosis

1. What are the criteria for diagnosis of SLE?
2. What are the arthritic symptoms of SLE?
3. What is Jaccoud's arthritis?
4. What labs are positive in SLE?
5. What is the treatment of SLE?

Answers:
1. 4/11 of the following: malar butterfly rash, discoid rash, photosensitivity, oral painless ulcers, arthritis (nonerosive), serositis, renal d/o, neurologic d/o, hematologic d/o, immunologic test positive (LE cell, anti-DNA, anti-SM, or false pos syphilis), ANA positive.
2. Involves small jts of hands, wrist, knees; symmetric; nonerosive; subQ nodules; Jaccoud's arthritis.
3. Nonerosive deforming arthritis, resulting in ulnar deviations of fingers and subluxation that is reversible early.
4. Depressed complement C3 and C4, Ds-DNA, anti-SM.
5. NSAIDs, steroids, antimalarials, methotrexate, cyclophosphamide, azathioprine, cyclosporine A.