Disease modifying anti-rheumatic drugs

1. What are poor prognostic factors for RA?
2. What are the safest disease-modifying drugs for RA?
3. What are the moderately toxic disease-modifying drugs for RA?
4. What are the most toxic disease-modifying drugs for RA?
5. What are non disease modifying drugs for RA?

Answers:
1. Rheumatoid nodules, RF+, erosive disease on X-ray, persistent synovitis, insidious onset.
2. Hydroxychloroquine, sulfasalazine, auranofin.
3. Methotrexate, cyclosporine, gold, azathioprine, D-penicillamine.
4. Chlorambucil, cyclophosphamide.
5. NSAIDs, corticosteroids.